Modeling substrate concentration in skeletal muscle
نویسندگان
چکیده
منابع مشابه
Modeling of active skeletal muscle
In this contribution a continuum constitutive model for the passive and active mechanical response of skeletal muscle tissue is presented. Within the verification of the model’s predictive capabilities and its numerical behaviour, a benchmark simulation is introduced. The presented model allows for simulation of complex soft tissue structures and their interactions. In a numerical example, an a...
متن کاملChiral Orientation of Skeletal Muscle Cells Requires Rigid Substrate
Reconstitution of tissue morphology with inherent left–right (LR) asymmetry is essential for tissue/organ functions. For skeletal muscle, the largest tissue in mammalian organisms, successful myogenesis requires the regulation of the LR asymmetry to form the appropriate muscle alignment. However, the key factor for reproducing the LR asymmetry of skeletal tissues in a controllable, engineering ...
متن کاملRelationship of C5L2 Receptor to Skeletal Muscle Substrate Utilization
OBJECTIVE To investigate the role of Acylation Stimulating Protein (ASP) receptor C5L2 in skeletal muscle fatty acid accumulation and metabolism as well as insulin sensitivity in both mice and human models of diet-induced insulin resistance. DESIGN AND METHODS Male wildtype (WT) and C5L2 knockout (KO) mice were fed a low (LFD) or a high (HFD) fat diet for 10 weeks. Intramyocellular lipid (IMC...
متن کاملToll-like receptor 4 modulates skeletal muscle substrate metabolism.
Toll-like receptor 4 (TLR4), a protein integral to innate immunity, is elevated in skeletal muscle of obese and type 2 diabetic humans and has been implicated in the development of lipid-induced insulin resistance. The purpose of this study was to examine the role of TLR4 as a modulator of basal (non-insulin-stimulated) substrate metabolism in skeletal muscle with the hypothesis that its activa...
متن کاملSkeletal muscle lipid concentration quantified by magnetic resonance imaging.
BACKGROUND Skeletal muscle lipid is associated with obesity and type 2 diabetes and may be altered by diet, physical activity, and weight loss. OBJECTIVE We explored the utility of magnetic resonance imaging (MRI) for quantifying the lipid concentration of muscle tissue in vivo. DESIGN Fat-selective MR images of the lower leg were taken in 8 normal-weight [body mass index (in kg/m(2)) < or ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Mathematical and Computer Modelling
سال: 1999
ISSN: 0895-7177
DOI: 10.1016/s0895-7177(99)00027-8